DATA

Below are the amino acid frequencies for the H1, H3, and H5 proteins.

Below is the protein sequence alignment for H5, H1, H3, and an older version of H1 in Texas (in that order, vertically)

K-means clustering of the genomes for the four HA proteins in Texas

GROUP
H1N1 Texas 0

H5N1 Texas 0

H1N1 Texas 0

H3N2 Texas 1

Hierarchical clustering of the genomes for the four HA proteins found in Texas

Below is the protein sequence alignment for H5, H1, H3 in Thailand (in that order, vertically)

K-means clustering of the genomes for the three HA proteins in Thailand

GROUP

H3N2 Thailand 0

H1N1 Thailand 1

H5N1 Thailand 1

Hierarchical clustering of the genomes for the three HA proteins found in Thailand

Sources:

Lu, Guoqing. "Influenza A Virus Genotype Tool - Browse Genotype Database." Influenza A Virus Genotype Tool - Browse Genotype Database. FluGenome, n.d. Web. 27 Apr. 2014. <http://flugenome.org/show_genomes.php>.

Abate, Tom. "Stanford Researchers Take a Step toward Developing a 'universal' Flu Vaccine." Stanford University. N.p., 20 Dec. 2013. Web. 27 Apr. 2014. <http://news.stanford.edu/news/2013/december/universal-flu-vaccine-121813.html>.

Paddock, Catherine, PhD. "Universal Flu Vaccine Closer after Natural Immunity Study." Medical News Today. MediLexicon International, 23 Sept. 2013. Web. 27 Apr. 2014. <http://www.medicalnewstoday.com/articles/266447.php>.

Saranya Sridhar, Shaima Begom, Alison Bermingham, Katja Hoschler, Walt Adamson, William Carman, Thomas Bean, Wendy Barclay, Jonathan J Deeks, Ajit Lalvani. Cellular immune correlates of protection against symptomatic pandemic influenza. Nature Medicine, 2013; DOI: 10.1038/nm.3350

"Cobalt Constraint-based Multiple Protein Alignment Tool." NCBI. U.S. National Library of Medicine, 28 Oct. 2009. Web. 27 Apr. 2014.

"Types of Influenza Viruses." Centers for Disease Control and Prevention. Centers for Disease Control and Prevention, 15 Jan. 2014. Web. 28 Apr. 2014.